Effect of tacrolimus versus cyklosporine on glukose metabolism of pancreas and kidney recipients in the late (> 8 years) posttransplant period
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002529" target="_blank" >RIV/00023001:_____/11:00002529 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S004113451101339X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S004113451101339X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.transproceed.2011.09.060" target="_blank" >10.1016/j.transproceed.2011.09.060</a>
Alternative languages
Result language
angličtina
Original language name
Effect of tacrolimus versus cyklosporine on glukose metabolism of pancreas and kidney recipients in the late (> 8 years) posttransplant period
Original language description
Diabetogenic effects of immunosuppressive agents are of great importance in pancreas or islet transplantation. The aim of our study was to compare the glucose metabolism in type 1 diabetic kidney and pancreas recipients on tacrolimus (Tacro) versus cyclosporine-based (Cyclo) immunosuppression in the late posttransplant period. We examined 26 insulinindependent patients with stabile good renal function. They were at least 7 years after simultaneous pancreas and kidney transplantation and with unchanged immunosuppressive therapy for at least 6 years. The mean follow-up in Tacro (n 13) and Cyclo (n 13) groups were 9.7 1.9 and 10.9 1.3 years, respectively (P .08). Fasting glycemia, insulin levels, glycosylated hemoglobin (HbA1c), a standard intravenous glucose tolerance test (IVGTT) with coefficient of glucose assimilation (KG) calculation and trough Tacro/Cyclo levels were assessed. Insulin sensitivity and insulin secretion were evaluated using the homeostasis model assessment (HOMA-IR, H
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Transplantation Proceedings
ISSN
0041-1345
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
3270-3272
UT code for WoS article
000297485500031
EID of the result in the Scopus database
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