The effect of epigenetic factors on differentiations of pancreatic progenitor cells into insulin-producings cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002530" target="_blank" >RIV/00023001:_____/11:00002530 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0041134511014084" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0041134511014084</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.transproceed.2011.10.025" target="_blank" >10.1016/j.transproceed.2011.10.025</a>
Alternative languages
Result language
angličtina
Original language name
The effect of epigenetic factors on differentiations of pancreatic progenitor cells into insulin-producings cells
Original language description
Differentiation of pancreatic progenitors into insulin-producing cells is regulated by various transcription factors. To be expressed the genes coding these transcription factors need to be in accessible DNA. Whether a particular gene is present in a form of active euchromatin structure with accessible DNA or in an inactive heterochromatin structure with inaccessible DNA is determined by various epigenetic modifications. We studied the effect of epigenetic modifiers on differentiation of human nonendocrine cells into insulin-producing cells with the aim to evaluate the effect of epigenetic modifications in that process. Within 3 days of cultivation nonendocrine cells form isletlike cell clusters (ILCCs) containing mainly cytokeratin-19-positive cells.After cultivation with epigenetic modifiers and further differentiation, the highest number of C-peptide-positive cells (10.3% 2.9%) as well as glucagon-positive cells (7.2% 2.8%) was observed in a samplesupplemented with a combination of
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Transplantation Proceedings
ISSN
0041-1345
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
3212-3216
UT code for WoS article
000297485500017
EID of the result in the Scopus database
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