Statistical bias in seeking the left ventricular endocardial sweet spot for cardiac resychronization therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002775" target="_blank" >RIV/00023001:_____/11:00002775 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0735109710048266" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0735109710048266</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jacc.2010.09.060" target="_blank" >10.1016/j.jacc.2010.09.060</a>

Result language
angličtina
Original language name
Statistical bias in seeking the left ventricular endocardial sweet spot for cardiac resychronization therapy
Original language description
The letter is challenging the conclusions of the two studies in patients with ischemic cardiomyopathy (Spragg DD et al. J Am Coll Cardiol 2010;56:774-81 and Derval N et al. J Am Coll Cardiol 2010;55:566-75) which reported that left ventricular endocardial pacing used for resynchronization therapy is capable of dramatic improvements in left ventricular systolic function compared to conventional epicardial pacing. Left ventricular sweet spot was sought among a considerable number of left ventricular endocardial sites in these studies and the correction for multiple measurements design was not performed. We demonstrated by mathematical modeling that a relatively small measurement error projects into a rather wide range of extreme hemodynamic indices resulting in significant overestimation of hemodynamic impact of pacing from the "optimum" site. It was concluded that an endocardial approach to cardiac resynchronization is a promising concept, but adequate experimental design and correct da
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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