A novel technique for the transplantation of pancreatic islets within a vascularized device into the greater omentum to achieve insulin independence

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00056313" target="_blank" >RIV/00023001:_____/12:00056313 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S0002961011002601/1-s2.0-S0002961011002601-main.pdf?_tid=608d44861aa4c1b772ad480720a70753&acdnat=1342609987_5f154cc09aa9b37bb491144999049c7a" target="_blank" >http://ac.els-cdn.com/S0002961011002601/1-s2.0-S0002961011002601-main.pdf?_tid=608d44861aa4c1b772ad480720a70753&acdnat=1342609987_5f154cc09aa9b37bb491144999049c7a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.amjsurg.2011.02.009" target="_blank" >10.1016/j.amjsurg.2011.02.009</a>

Result language
angličtina
Original language name
A novel technique for the transplantation of pancreatic islets within a vascularized device into the greater omentum to achieve insulin independence
Original language description
BACKGROUND: The greater omentum with its vascularization and blood flow has been considered as a location for islet transplantation; however, there is a need to provide a controlled and protected site for the islets within the omentum that would be applicable to donor islets and future stem cell technologies. Here we describe the use of a novel device implanted within the omentum with a subcutaneous delivery port that offers an environment for donor islets. METHODS: A prototype cell pouch device was wrapped in the greater omentum and an islet implantation port was exposed subcutaneously in diabetic Lewis rats. After tissue growth throughout the device, islet isografts were implanted and long-term glucose control was evaluated. RESULTS: By using this technique, 7 of 10 diabetic rat recipients showed long-term normal blood glucose levels after minimal islet dose transplants. Histologic assessment revealed collagen formation and vascularization within the device. CONCLUSIONS: The implante
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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