Prasugrel versus clopidogrel for acute coronary Syndromes without revascularization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00057974" target="_blank" >RIV/00023001:_____/12:00057974 - isvavai.cz</a>
Result on the web
<a href="http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205512" target="_blank" >http://www.nejm.org/doi/pdf/10.1056/NEJMoa1205512</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1056/NEJMoa1205512" target="_blank" >10.1056/NEJMoa1205512</a>
Alternative languages
Result language
angličtina
Original language name
Prasugrel versus clopidogrel for acute coronary Syndromes without revascularization
Original language description
The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. Methods:In this double-blind, randomized trial, in a primary analysis involving 7243 patients under the age of 75 years receiving aspirin, we evaluated up to 30 months of treatment with prasugrel (10 mg daily) versus clopidogrel (75 mg daily). In a secondary analysis involving 2083 patients 75 years of age or older, we evaluated 5 mg of prasugrel versus 75 mg of clopidogrel. Results: At a median follow-up of 17 months, the primary end point of death from cardiovascular causes, myocardial infarction, or stroke among patients under the age of 75 years occurred in 13.9% of the prasugrel group and 16.0% of the clopidogrel group (hazard ratio in the prasugrel group, 0.91; 95% confidence interval [CI], 0.79 to 1.05; P = 0.21). Similar results were observed in the overall population. The prespecified
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
New England journal of medicine
ISSN
0028-4793
e-ISSN
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Volume of the periodical
367
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
1297-1309
UT code for WoS article
000309406100006
EID of the result in the Scopus database
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