Prediction of organ transplant rejection by HLA-specific and non-HLA antibodies brief literature review

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00057908" target="_blank" >RIV/00023001:_____/13:00057908 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1744-313X.2012.01139.x/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/j.1744-313X.2012.01139.x/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1744-313X.2012.01139.x" target="_blank" >10.1111/j.1744-313X.2012.01139.x</a>

Result language
angličtina
Original language name
Prediction of organ transplant rejection by HLA-specific and non-HLA antibodies brief literature review
Original language description
The application of soli-phase assays for detection and definition of Human luecocyty antigen (HLA)- specific antibodies has significantly facilitated the diagnosis and monitoring of treatment of antibody-mediated tejection (AMR). There is, however, a major discusion in the literature concerning the clinical relevance of the use of the Luminex technique for the prediction of celluar and/or AMR and survival. This may be explained on one hand by the complexities of the method and on the other by variationsin patient demographic charakteristics, immunosuppression and other factors. As far as non-HLA antibodies, it is clear that they may induce AMR; nevertheless,a difficult problem in their definition remains the fact that most of the non-HLA antigens still remain to be identified. Hereby is a short literature review of several recent publications discussing the role of HLA- and non-HLA-specific antibodies in organ transplant rejection and survival.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/NT11262" target="_blank" >NT11262: Approach to patients with preformed antibodies before heart transplantation.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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