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Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00058607" target="_blank" >RIV/00023001:_____/13:00058607 - isvavai.cz</a>

  • Result on the web

    <a href="http://eurjhf.oxfordjournals.org/content/15/7/776.full.pdf+html" target="_blank" >http://eurjhf.oxfordjournals.org/content/15/7/776.full.pdf+html</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/eurjhf/hft026" target="_blank" >10.1093/eurjhf/hft026</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction

  • Original language description

    Exercise intolerance is a hallmark of heart failure with preserved ejection fraction (HFpEF), yet its mechanisms remain unclear. The current study sought to determine whether increases in cardiac output (CO) during exercise are appropriately matched to metabolic demands in HFpEF. Patients with HFpEF (n 109) and controls (n 73) exercised to volitional fatigue with simultaneous invasive (n 96) or non-invasive (n 86) haemodynamic assessment and expired gas analysis to determine oxygen consumption (VO2) during upright or supine exercise. At rest, HFpEF patients had higher LV filling pressures but similar heart rate, stroke volume, EF, and CO. During supine and upright exercise, HFpEF patients displayed lower peak VO2 coupled with blunted increases in heartrate, stroke volume, EF, and CO compared with controls. LV filling pressures increased dramatically in HFpEF patients, with secondary elevation in pulmonary artery pressures. Reduced peak VO2 in HFpEF patients was predominantly attributa

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European journal of heart failure

  • ISSN

    1388-9842

  • e-ISSN

  • Volume of the periodical

    15

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    776-785

  • UT code for WoS article

    000320857400013

  • EID of the result in the Scopus database