Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00058607" target="_blank" >RIV/00023001:_____/13:00058607 - isvavai.cz</a>
Result on the web
<a href="http://eurjhf.oxfordjournals.org/content/15/7/776.full.pdf+html" target="_blank" >http://eurjhf.oxfordjournals.org/content/15/7/776.full.pdf+html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/eurjhf/hft026" target="_blank" >10.1093/eurjhf/hft026</a>
Alternative languages
Result language
angličtina
Original language name
Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction
Original language description
Exercise intolerance is a hallmark of heart failure with preserved ejection fraction (HFpEF), yet its mechanisms remain unclear. The current study sought to determine whether increases in cardiac output (CO) during exercise are appropriately matched to metabolic demands in HFpEF. Patients with HFpEF (n 109) and controls (n 73) exercised to volitional fatigue with simultaneous invasive (n 96) or non-invasive (n 86) haemodynamic assessment and expired gas analysis to determine oxygen consumption (VO2) during upright or supine exercise. At rest, HFpEF patients had higher LV filling pressures but similar heart rate, stroke volume, EF, and CO. During supine and upright exercise, HFpEF patients displayed lower peak VO2 coupled with blunted increases in heartrate, stroke volume, EF, and CO compared with controls. LV filling pressures increased dramatically in HFpEF patients, with secondary elevation in pulmonary artery pressures. Reduced peak VO2 in HFpEF patients was predominantly attributa
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European journal of heart failure
ISSN
1388-9842
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
776-785
UT code for WoS article
000320857400013
EID of the result in the Scopus database
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