IL-4 polymorphisms, HRCT score and lung tissue markers in idiopathic pulmonary fibrosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00058738" target="_blank" >RIV/00023001:_____/13:00058738 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/13:00396456 RIV/00064190:_____/13:#0000588
Result on the web
<a href="http://ac.els-cdn.com/S0198885913002127/1-s2.0-S0198885913002127-main.pdf?_tid=2e72e306-745d-11e3-84cd-00000aab0f27&acdnat=1388743111_c3cc3a8127cf51b1e24bdc17b1abaf1c" target="_blank" >http://ac.els-cdn.com/S0198885913002127/1-s2.0-S0198885913002127-main.pdf?_tid=2e72e306-745d-11e3-84cd-00000aab0f27&acdnat=1388743111_c3cc3a8127cf51b1e24bdc17b1abaf1c</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.humimm.2013.07.011" target="_blank" >10.1016/j.humimm.2013.07.011</a>

Result language
angličtina
Original language name
IL-4 polymorphisms, HRCT score and lung tissue markers in idiopathic pulmonary fibrosis
Original language description
Aims: We studied the influence of IL-4 gene polymorphisms on the IPF phenotype, i.e., extent of radiological changes (HRCT interstitial (IS) and alveolar (AS) score) and histopathological markers from lung biopsies. Patients and methods: 46 IPF patientsunderwent genotyping, 43 of them had HRCT and 14 patients had a surgical lung biopsy. The HRCT scans were evaluated for AS and IS. The histopathological evaluation comprised myofibroblast foci (MF), intensity of inflammation and fibrosis (Ashcroft score)and numbers of eosinophils and granulomas. For immunohistochemical evaluation primary antibodies against PAR-2, CD124, TGF beta, YY-1 and TSLP were used. The IL-4 and IL-4 R alpha gene polymorphisms were characterized. Results: We found a correlation between eosinophils in lung biopsies and AS. The Ashcroft score was higher in IL-4 HA 2 GCC and MF were more frequent in IL-4 HA 2 TCC carriers. A relationship was found between IL-4 (-1098) A2 T and PAR-2 expression and IL-4 (-590) A1 T, I
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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