Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00058760" target="_blank" >RIV/00023001:_____/13:00058760 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S2213177913001248/1-s2.0-S2213177913001248-main.pdf?_tid=94441636-8296-11e3-82e8-00000aab0f27&acdnat=1390307079_ed84d8efc224ca7767fd08705272bd65" target="_blank" >http://ac.els-cdn.com/S2213177913001248/1-s2.0-S2213177913001248-main.pdf?_tid=94441636-8296-11e3-82e8-00000aab0f27&acdnat=1390307079_ed84d8efc224ca7767fd08705272bd65</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jchf.2013.03.008" target="_blank" >10.1016/j.jchf.2013.03.008</a>
Alternative languages
Result language
angličtina
Original language name
Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact
Original language description
Objectives: The purpose of this study was to compare the prognostic impact of clinical and biomarker correlates of resting heart rate (HR) and chronotropic incompetence in heart failure (HF) patients. Background: The mechanisms and underlying pathophysiological influences of HR abnormalities in HF are incompletely understood. Methods: In a prospective pilot study, 81 patients with advanced systolic HF (97% were receiving beta-blockers) and 25 age-, sex-, and body-size matched healthy controls underwentmaximal cardiopulmonary exercise testing with sampling of neurohormones and biomarkers. Results: Two-thirds of HF patients met criteria for chronotropic incompetence. Resting HR and HR reserve (HRR, a measure of chronotropic response) were not correlatedwith each other and were associated with distinct biomarker profiles. Resting HR correlated with increased myocardial stress (B-type natriuretic peptide [BNP]: r 1/4 0.26; pro A-type natriuretic peptide: r 1/4 0.24; N-terminal(NT)-proBNP
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LH12052" target="_blank" >LH12052: Use of dynamic testing of myocardial biomarkers for early detection and prognostication of heart failure</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the American college of cardiology : Heart failure
ISSN
2213-1779
e-ISSN
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Volume of the periodical
1
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
259-266
UT code for WoS article
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EID of the result in the Scopus database
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