Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00059172" target="_blank" >RIV/00023001:_____/13:00059172 - isvavai.cz</a>

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0016508513002916" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0016508513002916</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1053/j.gastro.2013.02.042" target="_blank" >10.1053/j.gastro.2013.02.042</a>

Result language

angličtina

Original language name

Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis

Original language description

BACKGROUND & AIMS: Patients with cirrhosis hospitalized for an acute decompensation (AD) and organ failure are at risk for imminent death and considered to have acute-on-chronic liver failure (ACLF). However, there are no established diagnostic criteriafor ACLF, so little is known about its development and progression. We aimed to identify diagnostic criteria of ACLF and describe the development of this syndrome in European patients with AD. METHODS: We collected data from 1343 hospitalized patients with cirrhosis and AD from February to September 2011 at 29 liver units in 8 European countries. We used the organ failure and mortality data to define ACLF grades, assess mortality, and identify differences between ACLF and AD. We established diagnostic criteria for ACLF based on analyses of patients with organ failure (defined by the chronic liver failure-sequential organ failure assessment [ CLIF-SOFA] score) and high 28-day mortality rate (> 15%). RESULTS: Of the patients assessed, 303

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Gastroenterology

ISSN

0016-5085

e-ISSN

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Volume of the periodical

144

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

21

Pages from-to

1426-"U189"

UT code for WoS article

000319498500026

EID of the result in the Scopus database

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