Tubular atrophy and low netrin-1 gene expression are associated with delayed kidney allograft function
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00058896" target="_blank" >RIV/00023001:_____/14:00058896 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1097/TP.0b013e3182a95d04" target="_blank" >http://dx.doi.org/10.1097/TP.0b013e3182a95d04</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/TP.0b013e3182a95d04" target="_blank" >10.1097/TP.0b013e3182a95d04</a>
Alternative languages
Result language
angličtina
Original language name
Tubular atrophy and low netrin-1 gene expression are associated with delayed kidney allograft function
Original language description
BACKGROUND: Delayed graft function (DGF) caused by ischemia/reperfusion injury (I/RI) negatively influences the outcome of kidney transplantation. This prospective single-center study characterized the intrarenal transcriptome during I/RI as a means of identifying genes associated with DGF development. METHODS: Characterization of the intrarenal transcription profile associated with I/RI was carried out on three sequential graft biopsies from respective allografts before and during transplantation. Theintragraft expression of 92 candidate genes was measured using quantitative real-time reverse transcriptase polymerase chain reaction (2) in delayed (n=9) and primary function allografts (n=26). RESULTS: Cold storage was not associated with significant changes to the expression profile of the target gene transcripts; however, up-regulation of 16 genes associated with enhanced activation of innate and adaptive immune responses and apoptosis was observed after reperfusion. Multivariate log
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Transplantation
ISSN
0041-1337
e-ISSN
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Volume of the periodical
97
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
176-183
UT code for WoS article
000335837900015
EID of the result in the Scopus database
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