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Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00058941" target="_blank" >RIV/00023001:_____/14:00058941 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/14:10292022

  • Result on the web

    <a href="http://onlinelibrary.wiley.com/doi/10.1111/1440-1681.12204/abstract;jsessionid=74F56A02F0B7EE26A93700D366959A66.f03t04" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/1440-1681.12204/abstract;jsessionid=74F56A02F0B7EE26A93700D366959A66.f03t04</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/1440-1681.12204" target="_blank" >10.1111/1440-1681.12204</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats

  • Original language description

    The aim of the present study was to test the hypothesis that increasing kidney tissue concentrations of epoxyeicosatrienoic acids (EETs) by preventing their degradation to the biologically inactive dihydroxyeicosatrienoic acids (DHETEs) using blockade ofsoluble epoxide hydrolase (sEH) would attenuate the progression of chronic kidney disease (CKD). Ren-2 transgenic rats (TGR) after 5/6 renal mass reduction (5/6 NX) served as a model of CKD associated with angiotensin (Ang) II-dependent hypertension. Soluble epoxide hydrolase was inhibited using cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid (c-AUCB; 3mg/L drinking water) for 20weeks after 5/6 NX. Sham-operated normotensive transgene-negative Hannover Sprague-Dawley (HanSD) rats served ascontrols. When applied in TGR subjected to 5/6 NX, c-AUCB treatment improved survival rate, prevented the increase in blood pressure, retarded the progression of cardiac hypertrophy, reduced proteinuria and the degree of glomerular and t

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical and Experimental Pharmacology and Physiology

  • ISSN

    0305-1870

  • e-ISSN

  • Volume of the periodical

    41

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

    227-237

  • UT code for WoS article

    000332924300011

  • EID of the result in the Scopus database