Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin-angiotensin system

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00058966" target="_blank" >RIV/00023001:_____/14:00058966 - isvavai.cz</a>
Result on the web
<a href="http://www.nature.com/hr/journal/v37/n8/pdf/hr201479a.pdf" target="_blank" >http://www.nature.com/hr/journal/v37/n8/pdf/hr201479a.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/hr.2014.79" target="_blank" >10.1038/hr.2014.79</a>

Result language
angličtina
Original language name
Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin-angiotensin system
Original language description
Chronic immunosuppressive therapy is often complicated by the development of both arterial hypertension and renal dysfunction. The principal aim of this study was to assess the effects of dual inhibition of renin-angiotensin system (RAS) and other antihypertensive treatment on blood pressure and renal function in normotensive and hypertensive Fawn-Hooded (FH) strains during chronic calcineurin inhibitor (CNI) administration. Combinations of perindopril (5 mg kg(-1) per day) and losartan (50 mg kg(-1) per day) or amlodipine (6 mg kg(-1) per day) and metoprolol (80 mg kg(-1) per day) were administered to normotensive (FHL) and hypertensive (FHH) rats, fed with diet containing tacrolimus (Tac; 12 mg kg(-1) per day). Tac-induced arterial hypertension in both animal strains (FHL: 151+-4; FHH: 198+-6 mm Hg) was prevented by dual RAS inhibition (FHL: 132+-3 mm Hg, P<0.05; FHH: 153+-3 mm Hg, P<0.05) as well as by a combination of amlodipine and metoprolol (FHL: 136+-3 mm Hg, P<0.05; FHH: 166+-
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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