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Effects of mtDNA in SHR-mt(F344) versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059027" target="_blank" >RIV/00023001:_____/14:00059027 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985823:_____/14:00433305

  • Result on the web

    <a href="http://physiolgenomics.physiology.org/content/46/18/671" target="_blank" >http://physiolgenomics.physiology.org/content/46/18/671</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1152/physiolgenomics.00069.2014" target="_blank" >10.1152/physiolgenomics.00069.2014</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effects of mtDNA in SHR-mt(F344) versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction

  • Original language description

    Common inbred strains of the laboratory rat can be divided into four major mitochondrial DNA (mtDNA) haplotype groups represented by the BN, F344, LEW, and SHR strains. In the current study, we investigated the metabolic and hemodynamic effects of the SHR vs. F344 mtDNA by comparing the SHR vs. SHR-mt(F344) conplastic strains that are genetically identical except for their mitochondrial genomes. Altogether 13 amino acid substitutions in protein coding genes, seven single nucleotide polymorphisms in tRNAgenes, and 12 single nucleotide changes in rRNA genes were detected in F344 mtDNA compared with SHR mtDNA. Analysis of oxidative phosphorylation system (OXPHOS) in heart left ventricles (LV), muscle, and liver revealed reduced activity and content of several respiratory chain complexes in SHR-mt(F344) conplastic rats compared with the SHR strain. Lower function of OXPHOS in LV of conplastic rats was associated with significantly increased relative ventricular mass and reduced fractional

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FB - Endocrinology, diabetology, metabolism, nutrition

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological genomics

  • ISSN

    1094-8341

  • e-ISSN

  • Volume of the periodical

    46

  • Issue of the periodical within the volume

    18

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    671-678

  • UT code for WoS article

    000341705900001

  • EID of the result in the Scopus database