Acute liver failureiInduced by thioacetamide: Selection of optimal dosage in wistar and lewis rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059060" target="_blank" >RIV/00023001:_____/14:00059060 - isvavai.cz</a>

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/2014/4_14.htm" target="_blank" >http://www.biomed.cas.cz/physiolres/2014/4_14.htm</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Acute liver failureiInduced by thioacetamide: Selection of optimal dosage in wistar and lewis rats

Original language description

Acute liver failure (ALF) is a clinical condition with very high mortality rate. Its pathophysiological background is still poorly understood, which necessitates a search for optimal experimental ALF models with features resembling those of the human disorder. Taking into consideration reproducibility of induction of ALF, adequate animal size, cost of animals, the required time gap between insult and death of animals ("therapeutic window"), potential risk to investigator and other aspects, administration of thioacetamide (TAA) in rats is currently most recommended. However, the fundamental details of this ALF model have not yet been evaluated. This prompted us to investigate, first, the course of ALF as induced by intraperitoneal TAA at doses increasing from 175 to 700 mg/kg BW per day. The animals' survival rate, plasma alanine and aspartate aminotransferase activities, and bilirubin and ammonia levels were determined over the follow-up period. Second, we examined whether Wistar and L

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

—

Volume of the periodical

63

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

13

Pages from-to

491-503

UT code for WoS article

000342568400010

EID of the result in the Scopus database

—