Sterol regulatory element binding protein 2 overexpression is associated with reduced adipogenesis and ectopic fat accumulation in transgenic spontaneously hypertensive rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059109" target="_blank" >RIV/00023001:_____/14:00059109 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/14:00437658

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/63/63_587.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/63/63_587.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Sterol regulatory element binding protein 2 overexpression is associated with reduced adipogenesis and ectopic fat accumulation in transgenic spontaneously hypertensive rats

Original language description

It has been reported that the major function of the sterol regulatory element binding protein 2 (SREBP-2) is to activate preferentially cholesterol biosynthesis in liver and adipose tissue rather than fatty acid synthesis. In the current study, we analyzed the effects of overexpression of human dominantpositive SREBP-2 transgene under control of PEPCK promoter in the spontaneously hypertensive rat (SHR) on lipid and glucose metabolism. Transgenic overexpression of SREBP-2 was associated with significantly higher hepatic triglycerides (20.4 +/- 0.9 vs. 17.0 +/- 0.05 mu mol/g, P < 0.05) but not cholesterol (10.6 +/- 0.4 vs. 10.9 +/- 0.4 mu mol/g) and decreased relative weight of epididymal fat pad (0.73 +/- 0.03 vs. 0.83. 0.03, P < 0.05). In addition, muscle triglyceride (15.8 +/- 3.7 vs. 8.5 +/- 1.2 mu mol/g, P < 0.001) and cholesterol (3.6 +/- 0.5 vs. 2.1 +/- 0.1 mu mol/g, P < 0.05) concentrations were significantly increased in transgenic rats when compared to SHR controls. Ectopic fa

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/LH12061" target="_blank" >LH12061: Identification of molecular and functional basis of pathophysiological phenotypes in the spontaneously hypertensive rat</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

587-590

UT code for WoS article

000345590100008

EID of the result in the Scopus database

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