Donsumab associated with bone density increase and clinical improvement in a long-term hemodialysis patient. Case report and review of the literature

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059141" target="_blank" >RIV/00023001:_____/14:00059141 - isvavai.cz</a>

Result on the web

<a href="http://orbis.lfhk.cuni.cz/Acta_Medica/2014/2014_30.pdf" target="_blank" >http://orbis.lfhk.cuni.cz/Acta_Medica/2014/2014_30.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Donsumab associated with bone density increase and clinical improvement in a long-term hemodialysis patient. Case report and review of the literature

Original language description

Denosumab is a full length human monoclonal antibody binding to the receptor activator of nuclear factor kappa-B ligand (RANKL), mimicking the action of osteoprotegerin (OPG, natural decoy receptor of RANKL) and representing a novel therapy of osteoporosis, approved by FDA in 2010 (1). By its action on RANKL, denosumab reduces the signal that is essential for osteoclasts formation, maturation, function and survival. RANKL inhibition has no effect on osteoblasts. Denosumab is not cleared by the kidneys.In chronic kidney disease (CKD) dose adjustment of denosumab is not required but calcium and vitamin D supplementation is strongly recommended (2). So far, only few case reports or very limited case series describing the experience with denosumab in CKDhave been published. They all stopped the therapy after single dose because of hypocalcemia (3, 4, 5, 6, 7, 8) (Table 1). We present a case of successful treatment of osteoporosis in a young hemodialysis patient with repeated denosumab do

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta medica

ISSN

1211-4286

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

30-34

UT code for WoS article

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EID of the result in the Scopus database

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