Effect of evolocumab or ezetimibe added to moderateor high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia the LAPLACE-2 randomized clinical trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059164" target="_blank" >RIV/00023001:_____/14:00059164 - isvavai.cz</a>
Result on the web
<a href="http://jama.jamanetwork.com/article.aspx?articleid=1869210" target="_blank" >http://jama.jamanetwork.com/article.aspx?articleid=1869210</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1001/jama.2014.4030" target="_blank" >10.1001/jama.2014.4030</a>
Alternative languages
Result language
angličtina
Original language name
Effect of evolocumab or ezetimibe added to moderateor high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia the LAPLACE-2 randomized clinical trial
Original language description
IMPORTANCE In phase 2 studies, evolocumab, a fully human monoclonal antibody to PCSK9, reduced LDL-C levels in patients receiving statin therapy. OBJECTIVE To evaluate the efficacy and tolerability of evolocumab when used in combination with a moderate-vs high-intensity statin. CONCLUSIONS AND RELEVANCE In this 12-week trial conducted among patients with primary hypercholesterolemia and mixed dyslipidemia, evolocumab added to moderate-or high-intensity statin therapy resulted in additional LDL-C lowering. Further studies are needed to evaluate the longer-term clinical outcomes and safety of this approach for LDL-C lowering. DESIGN, SETTING, AND PATIENTS Phase 3, 12-week, randomized, double-blind, placebo-and ezetimibe-controlled study conducted betweenJanuary and December of 2013 in patients with primary hypercholesterolemia and mixed dyslipidemia at 198 sites in 17 countries
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JAMA
ISSN
0098-7484
e-ISSN
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Volume of the periodical
311
Issue of the periodical within the volume
18
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
1870-1882
UT code for WoS article
000335798100019
EID of the result in the Scopus database
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