Living-donor kidney transplantation for atypical haemolytic uremic syndrome with pre-emptive eculizumab use

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059363" target="_blank" >RIV/00023001:_____/15:00059363 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/tri.12440/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/tri.12440/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/tri.12440" target="_blank" >10.1111/tri.12440</a>

Result language

angličtina

Original language name

Living-donor kidney transplantation for atypical haemolytic uremic syndrome with pre-emptive eculizumab use

Original language description

Post-transplant recurrence of atypical hemolytic uremic syndrome (aHUS), an ultra-rare genetic disease, is high and associated with a poor prognosis. Several recent reports have provided encouraging findings regarding the use of eculizumab, an anti-C5 terminal complement inhibitor, when given at transplantation or, in the case of disease recurrence, after transplantation. The complement system is an important mediator of renal ischemia-reperfusion injury. Therefore, pre-emptive eculizumab might be effective to attenuate complement activation. Here, we report an aHUS patient with associated complement factor H (CFH) mutation who underwent eculizumab therapy for 2 months before living-unrelated donor kidney transplantation. Despite a successful post-operative course, the patient suffered from polyoma BK nephropathy at 3 months. After reduction of immunosuppression, he experienced steroid-sensitive acute rejection, despite receiving therapeutic levels of eculizumab. Otherwise, the 14-month eculizumab therapy follow-up was uneventful, and the graft function remained stable at 1.7 mg dL-1 at 12 months after transplantation. This case highlights the successful use of eculizumab therapy before and after transplantation to prevent aHUS recurrence and shows the possible pitfalls that may accompany such therapy.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

—

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transplant international

ISSN

0934-0874

e-ISSN

—

Volume of the periodical

28

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

366-369

UT code for WoS article

000350987000014

EID of the result in the Scopus database

—