Bortezomib-containing regimen for primary treatment of early antibody-mediated cardiac allograft rejection: a case report

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059500" target="_blank" >RIV/00023001:_____/15:00059500 - isvavai.cz</a>

Result on the web

<a href="http://progressintransplantation.com/doi/10.7182/pit2015934" target="_blank" >http://progressintransplantation.com/doi/10.7182/pit2015934</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7182/pit2015934" target="_blank" >10.7182/pit2015934</a>

Result language

angličtina

Original language name

Bortezomib-containing regimen for primary treatment of early antibody-mediated cardiac allograft rejection: a case report

Original language description

Evidence regarding the use of bortezomib-containing schemes in primary treatment of antibody-mediated rejection in heart transplant recipients is scarce. This case report presents the clinical experience with upstream use of bortezomib in primary treatment of early antibody-mediated rejection in an adult heart transplant recipient. Two cycles of bortezomib together with methylprednisolone, immunoadsorption, rituximab, and supplementary doses of intravenous immunoglobulin G reversed signs of heart failure, production of donor-specific antibodies, and findings of antibody-mediated rejection in biopsy. This treatment regimen was tolerated with only mild hematologic toxicity and proved to be successful during a 12-month follow-up. Primary treatment with a bortezomib-containing regimen appears to be a new therapeutic option for severe antibody-mediated rejection in heart transplant recipients. However, the efficacy and safety of this treatment need to be tested in prospective trials. (C) 2015 NATCO, The Organization for Transplant Professionals

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Progress in Transplantation

ISSN

1526-9248

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

147-152

UT code for WoS article

000356105200008

EID of the result in the Scopus database

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