Sex differences in experimentally induced colitis in mice: A role for estrogens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059548" target="_blank" >RIV/00023001:_____/15:00059548 - isvavai.cz</a>

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs10753-015-0180-7" target="_blank" >http://link.springer.com/article/10.1007%2Fs10753-015-0180-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10753-015-0180-7" target="_blank" >10.1007/s10753-015-0180-7</a>

Result language

angličtina

Original language name

Sex differences in experimentally induced colitis in mice: A role for estrogens

Original language description

Sex differences have been found in the incidence and progression of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. The reported differences in observational studies are controversial, and the effects of sex hormones on the pathogenesis of IBD are not clear. The aim of this study was to analyze sex differences in the progression of experimentally induced colitis. Experimental colitis was induced in adult mice by adding 2 % dextran sodium sulfate (DSS) into drinking water. Male and female mice were used as intact, gonadectomized, and supplemented with either estradiol or testosterone. In comparison to males, female mice with induced colitis had significantly longer colon (p < 0.05), lower decrease in body weight (p < 0.001), and lower stool consistency score (p < 0.05). Histopathological analysis showed less inflammatory infiltrates (p < 0.001) and crypt damage (p < 0.001) in female mice. Female mice with colitis had also lower concentration of TNF-alpha in colon homogenates (p < 0.01). Supplementation with estradiol in ovariectomized mice ameliorated the severity of colitis. Female mice are partially protected against chemically induced colitis. This protection seems to be mediated by estradiol.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Inflammation

ISSN

0360-3997

e-ISSN

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Volume of the periodical

38

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1996-2006

UT code for WoS article

000360847200029

EID of the result in the Scopus database

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