All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Molecular diagnostics identifies risks for graft dysfunction despite borderline histologic changes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059562" target="_blank" >RIV/00023001:_____/15:00059562 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/15:10306868 RIV/00216208:11140/15:10306868 RIV/00064190:_____/15:#0001125 RIV/00023736:_____/15:00011382

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S215717161532267X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S215717161532267X</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/ki.2015.211" target="_blank" >10.1038/ki.2015.211</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Molecular diagnostics identifies risks for graft dysfunction despite borderline histologic changes

  • Original language description

    The significance of borderline changes in kidney allograft biopsies is widely debated. To help resolve this, we studied differences in intrarenal gene expression patterns between early clinical and 3-month protocol biopsies, all of which had borderline histologic changes. The gene expression profiles in training set of patients by microarray analysis and data were validated in a larger cohort using RT-qPCR. There was greater expression of immunity-and inflammation-related genes in the early clinical biopsies compared to the 3-month protocol biopsies with borderline changes. In early clinically manifested borderline changes, graft deterioration within 24 months due to chronic rejection was associated with increased activation of immune, defense, and inflammatory processes. Regression modeling identified higher donor age and expression of macrophage receptor CLEC5A as risk factors for progression. In the 3-month protocol biopsies with borderline changes, graft dysfunction was associated with increased expression of fibrinogen complex transcripts. The discrimination power of fibrinogen was confirmed by cross-validation on two independent cohorts. Thus, our study highlights variations in gene expression between clinical and subclinical borderline changes despite similar histological findings. The data also support a recommendation for frequent patient monitoring, especially in those with borderline changes who received grafts from older donors.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30213 - Transplantation

Result continuities

  • Project

    <a href="/en/project/7E13020" target="_blank" >7E13020: Personalized minimization of immunosuppression after solid organ transplantation by biomarker-driven stratification of patients to improve long-term outcome and health-economic data of transplantation</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Kidney international

  • ISSN

    0085-2538

  • e-ISSN

  • Volume of the periodical

    88

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    785-795

  • UT code for WoS article

    000362219600019

  • EID of the result in the Scopus database

    2-s2.0-84942889787