Enhanced pulmonary vasodilator reserve and abnormal right ventricular pulmonary artery coupling in heart failure with preserved ejection fraction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059621" target="_blank" >RIV/00023001:_____/15:00059621 - isvavai.cz</a>
Result on the web
<a href="http://circheartfailure.ahajournals.org/content/8/3/542.full.pdf+html" target="_blank" >http://circheartfailure.ahajournals.org/content/8/3/542.full.pdf+html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.002114" target="_blank" >10.1161/CIRCHEARTFAILURE.114.002114</a>
Alternative languages
Result language
angličtina
Original language name
Enhanced pulmonary vasodilator reserve and abnormal right ventricular pulmonary artery coupling in heart failure with preserved ejection fraction
Original language description
Background Pulmonary hypertension and right ventricular (RV) dysfunction are common in patients with advanced heart failure with preserved ejection fraction (HFpEF), yet their underlying mechanisms remain poorly understood. We sought to examine RV-pulmonary artery (PA) functional reserve responses and RV-PA coupling at rest and during -adrenergic stimulation in subjects with earlier stage HFpEF. Conclusions Pulmonary hypertension in early stage HFpEF is related to partially reversible pulmonary vasoconstriction coupled with RV systolic and diastolic dysfunction, even in the absence of RV structural remodeling. Pulmonary vascular tone is more favorably responsive to -adrenergic stimulation in HFpEF than controls, suggesting a potential role for -agonists in the treatment of patients with HFpEF and pulmonary hypertension. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01418248.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Circulation heart failure
ISSN
1941-3289
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
542-550
UT code for WoS article
000357079700019
EID of the result in the Scopus database
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