Geometric ring annuloplasty as an adjunct to aortic valve repair: clinical investigation of the HAART 300 device

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059842" target="_blank" >RIV/00023001:_____/16:00059842 - isvavai.cz</a>

Result on the web

<a href="http://ejcts.oxfordjournals.org/content/49/3/987.full.pdf+html" target="_blank" >http://ejcts.oxfordjournals.org/content/49/3/987.full.pdf+html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ejcts/ezv234" target="_blank" >10.1093/ejcts/ezv234</a>

Result language

angličtina

Original language name

Geometric ring annuloplasty as an adjunct to aortic valve repair: clinical investigation of the HAART 300 device

Original language description

This study assessed the safety and efficacy of an internal geometric annuloplasty ring in a regulatory trial of aortic valve reconstruction (ClinicalTrials.gov Identifier: NCT01400841). Sixty-five patients with predominant moderate-to-severe trileaflet aortic insufficiency (AI) underwent aortic valve repair with an average age of 63 +/- 13 years (mean +/- SD). All had initial implantation of an internal aortic annuloplasty ring to correct annular dilatation and facilitate leaflet reconstruction. Leaflet plication was performed for prolapse in 80% of patients, and more complex leaflet procedures, usually employing autologous pericardium, were required in 22%. Ascending aortic and/or root aneurysms were replaced in 62%. Follow-up was for a maximum of 3 years and a mean of 2 years. No in-hospital operative mortalities, major complications or early or late valve-related events occurred. The annular diameter before repair was 26.5 +/- 2.3 mm, and the average ring diameter used was 21.5 +/- 1.6 mm. The preoperative AI grade (0-4) was 2.9 +/- 0.8 and improved after repair to 0.6 +/- 0.7 (P < 0.0001), as did the NYHA class. The mean valve gradient was 8.6 +/- 4.3 mmHg, and at 3 years, the Kaplan-Meier survival rate was 95%, with no valve-related mortality. Over the 3 years, aortic valve replacement was required in 7 patients (10.8%) for reasons usually related to surgical technique. Most repair failures occurred early, and results stabilized after 6 months. No structural complications of the rings were observed. Geometric ring annuloplasty was a safe and effective adjunct to aortic valve repair. Initial correction of annular dilatation seemed to facilitate overall reconstruction. Because most early repair failures were technical, increasing experience with geometric ring annuloplasty for aortic valve reconstruction has the potential to standardize and improve outcomes.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

—

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European journal of cardio-thoracic surgery

ISSN

1010-7940

e-ISSN

—

Volume of the periodical

49

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

987-993

UT code for WoS article

000372977500047

EID of the result in the Scopus database

—