Values of osteoprotegerin in aortic valve tissue in patients with significant aortic stenosis depend on the existence of concomitant coronary artery disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059996" target="_blank" >RIV/00023001:_____/16:00059996 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/16:43911070 RIV/00064173:_____/16:N0000051 RIV/75010330:_____/16:00011366

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S1054880715001702" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1054880715001702</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.carpath.2015.12.003" target="_blank" >10.1016/j.carpath.2015.12.003</a>

Result language

angličtina

Original language name

Values of osteoprotegerin in aortic valve tissue in patients with significant aortic stenosis depend on the existence of concomitant coronary artery disease

Original language description

Introduction: Calcific aortic valve stenosis (CAVS) is a serious clinical problem. The strongest predictor of CAVS progression is the amount of calcium in the aortic valve. The pathogenesis of CAVS is largely consistent with the pathogenesis of atherosclerosis; however, about 50% of patients with CAVS do not exhibit significant atherosclerosis. Cardiovascular calcification is currently considered an actively regulated process, in which the important role is attributed to the RANKL/RANK/OPG (receptor activator of nuclear factor kappa B ligand/RANK/osteoprotegerin) axis. We measured OPG levels in the tissue of calcified, stenotic aortic valves in relation to the presence or absence of coronary artery disease (CAD). Results: The highest tissue concentrations of OPG [median (pmol/L), 25th-75th percentile] were found in Group A [6.95, 3.96-18.37], which was significantly different compared to the other two groups (P=. 026 and .001, respectively). The levels of OPG in Group B [4.15, 2.47-9.16] and in Group C [2.25, 1.01-5.08] did not differ significantly (P=. 078); however, the lowest concentrations of OPG were found in Group C. Neither age nor gender in our study had effect on tissue levels of OPG (P=. 994 for gender; P=. 848 for age). Conclusion: Calcified and narrowed aortic valves, compared to the normal valves, were accompanied by a change in tissue concentrations of OPG, which is, in addition, dependent on the presence or absence of CAD. The highest tissue concentrations of OPG in ourwork were found in patients with significant aortic stenosis without concomitant CAD.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/NT13711" target="_blank" >NT13711: Platelet activation in calcified degenerative aortic stenosis</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cardiovascular pathology

ISSN

1054-8807

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

181-184

UT code for WoS article

000375860400002

EID of the result in the Scopus database

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