Interlobular arteries from 2-kidney, 1-clip goldblatt hypertensive rats' exhibit-impaired vasodilator response to epoxyeicosatrienoic acids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060012" target="_blank" >RIV/00023001:_____/16:00060012 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/16:10327949
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0002962916002056" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0002962916002056</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.amjms.2016.02.030" target="_blank" >10.1016/j.amjms.2016.02.030</a>
Alternative languages
Result language
angličtina
Original language name
Interlobular arteries from 2-kidney, 1-clip goldblatt hypertensive rats' exhibit-impaired vasodilator response to epoxyeicosatrienoic acids
Original language description
Background: Small renal arteries have a significant role in the regulation of renal hemodynamics and blood pressure (BP). To study potential changes in the regulation of vascular function in hypertension, we examined renal vasodilatory responses of small arteries from nonclipped kidneys of the 2-kidney, 1-clip Goldblatt hypertensive rats to native epoxyeicosatrienoic acids (EETs) that are believed to be involved in the regulation of renal vascular function and BP. A total of 2 newly synthesized EET analogues were also examined. Materials and Methods: Renal interlobular arteries isolated from the nonclipped kidneys on day 28 after clipping were preconstricted with phenylephrine, pressurized and the effects of a 14,15-EET analogue, native 14,15-EET and 11,12-ether-EET-8ZE, an analogue of 11,12-EET, on the vascular diameter were determined and compared to the responses of arteries from the kidneys of sham-operated rats. Results: In the arteries from nonclipped kidneys isolated in the maintenance phase of Goldblatt hypertension, the maximal vasodilatory response to 14,15-EET analogue was 30.1 +/- 2.8% versus 49.8 +/- 7.2% in sham-operated rats; the respective values for 11,12-ther-EET-8ZE were 31.4 +/- 6.4% versus 80.4 +/- 6%, and for native EETs they were 41.7 +/- 6.6% versus 62.8 +/- 4.4% (P = 0.05 for each difference). Conclusions: We propose that reduced vasodilatory action and decreased intrarenal bioavailability of EETs combined with intrarenal angiotensin II levels that are inappropriately high for hypertensive rats underlie functional derangements of the nonclipped kidneys of 2-kidney, 1-clip Goldblatt hypertensive rats. These derangements could play an important role in pathophysiology of sustained BP elevation observed in this animal model of human renovascular hypertension.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14011" target="_blank" >NT14011: The impact of bradykinin B2 receptor gene inactivation in mouse distal tubule on sodium handling in experimental models of hypertension</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American journal of the medical sciences
ISSN
0002-9629
e-ISSN
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Volume of the periodical
351
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
513-519
UT code for WoS article
000382666100013
EID of the result in the Scopus database
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