Donor-specific antibodies require preactivated immune system to harm renal transplant
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060021" target="_blank" >RIV/00023001:_____/16:00060021 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S235239641630250X/1-s2.0-S235239641630250X-main.pdf?_tid=6074f266-99eb-11e6-a3c7-00000aab0f02&acdnat=1477314869_05d8195977e03b5e82b940d2856d6015" target="_blank" >http://ac.els-cdn.com/S235239641630250X/1-s2.0-S235239641630250X-main.pdf?_tid=6074f266-99eb-11e6-a3c7-00000aab0f02&acdnat=1477314869_05d8195977e03b5e82b940d2856d6015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ebiom.2016.06.006" target="_blank" >10.1016/j.ebiom.2016.06.006</a>
Alternative languages
Result language
angličtina
Original language name
Donor-specific antibodies require preactivated immune system to harm renal transplant
Original language description
Background: It is an unresolved issue why some kidney transplant recipients with pretransplant donor-specific HLA antibodies (DSA) show a high transplant failure rate, whereas in other patients DSA do not harm the graft. We investigated whether help from preactivated T-cells might be necessary for DSA to exert a deleterious effect. Methods: The impact of pretransplant DSA and immune activation marker soluble CD30 (sCD30) on 3-year graft survival was analyzed in 385 presensitized kidney transplant recipients. Findings: A deleterious influence of pretransplant DSA on graft survival was evident only in patients who were positive for the immune activation marker sCD30. In the absence of sCD30 positivity, 3-year graft survival was virtually identical in patients with or without DSA (83.1 +/- 3.9% and 84.3 +/- 2.8%, P = 0.81). A strikingly lower 3-year graft survival rate of 62.1 +/- 6.4% was observed in patients who were both sCD30 and DSA positive (HR 2.92, P < 0.001). Even in the presence of strong DSA with }= 5000 MFI, the 3-year graft survival rate was high if the recipients were sCD30 negative. Interpretation: Pretransplant DSA have a significantly deleterious impact on graft survival only in the presence of high pretransplant levels of the activation marker sCD30. (C) 2016 The Authors. Published by Elsevier B.V.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EBioMedicine [online]
ISSN
2352-3964
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
July 2016
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
366-371
UT code for WoS article
000381622500046
EID of the result in the Scopus database
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