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Altered neural correlate of the self-agency experience in first-episode schizophrenia-spectrum patients: an fMRI study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060072" target="_blank" >RIV/00023001:_____/16:00060072 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/16:00090378 RIV/00216208:11120/16:43910991 RIV/65269705:_____/16:00066112 RIV/00023752:_____/16:43914876

  • Result on the web

    <a href="https://academic.oup.com/schizophreniabulletin/article-abstract/42/4/916/2413876/Altered-Neural-Correlate-of-the-Self-Agency?redirectedFrom=fulltext" target="_blank" >https://academic.oup.com/schizophreniabulletin/article-abstract/42/4/916/2413876/Altered-Neural-Correlate-of-the-Self-Agency?redirectedFrom=fulltext</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/schbul/sbv188" target="_blank" >10.1093/schbul/sbv188</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Altered neural correlate of the self-agency experience in first-episode schizophrenia-spectrum patients: an fMRI study

  • Original language description

    Background: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. Aims: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). Method: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). Results: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P <.05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Discussion: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FL - Psychiatry, sexology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT14291" target="_blank" >NT14291: Regional structural, functional and spectroscopic changes in insular region during an early stage of psychotic illness.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Schizophrenia bulletin

  • ISSN

    0586-7614

  • e-ISSN

  • Volume of the periodical

    42

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    916-925

  • UT code for WoS article

    000385280800013

  • EID of the result in the Scopus database