The effect of colesevelam treatment on bile acid and lipid metabolism and glycemic control in healthy men

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060164" target="_blank" >RIV/00023001:_____/16:00060164 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10333780

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/65/65_995.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/65/65_995.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The effect of colesevelam treatment on bile acid and lipid metabolism and glycemic control in healthy men

Original language description

The treatment of hypercholesterolemia with bile acid (BA) sequestrants results in upregulation of BA synthesis through the classical pathway initiated by cholesterol 7α-hydroxylase (CYP7A1). To characterize the detailed dynamics of serum lipid and BA concentrations and the BA synthesis rate in response to treatment with BA sequestrants and to determine whether the -203A/C promoter polymorphism of the CYP7A1 encoding gene (CYP7A1) affects such a response, this pilot study was carried out in healthy men (8 homozygous for the -203A allele and 8 homozygous for the -203C allele of CYP7A1). The subjects were treated for 28 days with colesevelam and blood was drawn for analysis before and on days 1, 3, 7, 14 and 28 of treatment. The response of lipids, BA, fibroblast growth factor-19 (FGF19) and 7α-hydroxy-4-cholesten-3-one (C4) to colesevelam did not differ between carriers of -203A and -203C alleles; their data were then aggregated for further analysis. Colesevelam treatment caused immediate suppression of FGF19 concentration and a fivefold increase in CYP7A1 activity, as assessed from C4 concentration, followed by a 17 % decrease in LDL-cholesterol. Although total plasma BA concentrations were not affected, the ratio of cholic acid/total BA rose from 0.25+-0.10 to 0.44+-0.16 during treatment at the expense of decreases in chenodeoxycholic and deoxycholic acid.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NT13151" target="_blank" >NT13151: Cholesterol 7alpha-hydroxylase polymorphism as a predictor cholesterolemia responsiveness</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

995-1003

UT code for WoS article

000391198200011

EID of the result in the Scopus database

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