Soluble BAFF cytokine levels and antibody-mediated rejection of the kidney allograft

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060240" target="_blank" >RIV/00023001:_____/16:00060240 - isvavai.cz</a>

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs00005-016-0428-4" target="_blank" >http://link.springer.com/article/10.1007%2Fs00005-016-0428-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00005-016-0428-4" target="_blank" >10.1007/s00005-016-0428-4</a>

Result language

angličtina

Original language name

Soluble BAFF cytokine levels and antibody-mediated rejection of the kidney allograft

Original language description

The B-cell activating factor (BAFF) cytokine has important functions for the survival and maturation of B lymphocytes, which implies that this cytokine might play a role in the development of antibody-mediated rejection (AMR) after kidney transplantation. In our study, we compared the concentrations of the soluble BAFF cytokine in kidney graft recipients with AMR and patients without rejection with the goal of testing the hypothesis whether BAFF level measurement might be useful as a diagnostic marker of AMR. The study included a cohort of 19 high-risk patients with diagnosed AMR and 17 control patients free of rejection. BAFF was measured in all patients before transplantation, during the rejection episodes, and three months after transplantation in patients free of rejection using the Luminex technique. Before transplantation, the serum concentrations of BAFF in patients with AMR and kidney recipients without rejection did not significantly differ. After transplantation, however, BAFF levels were significantly lower in patients with AMR and also in patients with concurrent humoral and cellular rejection compared with patients without rejection (p < 0.05 and p < 0.01, respectively). No correlation was found between BAFF and the production of donor-specific antibodies (DSA) before and after transplantation. Patients experiencing AMR and simultaneous cellular and AMR had significantly lower concentrations of BAFF in comparison with patients free of rejection.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archivum immunologiae et therapiae experimentalis

ISSN

0004-069X

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

47-53

UT code for WoS article

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EID of the result in the Scopus database

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