Complement in kidney transplantation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00075893" target="_blank" >RIV/00023001:_____/17:00075893 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fmed.2017.00066" target="_blank" >http://dx.doi.org/10.3389/fmed.2017.00066</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fmed.2017.00066" target="_blank" >10.3389/fmed.2017.00066</a>
Alternative languages
Result language
angličtina
Original language name
Complement in kidney transplantation
Original language description
The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or lectin pathway, resulting in the creation of anaphylatoxins C3a and C5a, possessing a vast spectrum of immune functions, and the assembly of terminal complement cascade, capable of direct cell lysis. The activation processes are tightly regulated; inappropriate activation of the complement cascade plays a significant role in many renal diseases including organ transplantation. Moreover, complement cascade is activated during ischemia/reperfusion injury processes and influences delayed graft function of kidney allografts. Interestingly, complement system has been found to play a role in both acute cellular and antibody-mediated rejections and thrombotic microangiopathy. Therefore, complement system may represent an interesting therapeutical target in kidney transplant pathologies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
<a href="/en/project/NV15-26865A" target="_blank" >NV15-26865A: Alloreactivity in living donor kidney transplantation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in medicine [online]
ISSN
2296-858X
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
May 30
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
"art. no. 66"
UT code for WoS article
000407114200001
EID of the result in the Scopus database
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