Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00075942" target="_blank" >RIV/00023001:_____/17:00075942 - isvavai.cz</a>

Result on the web

<a href="http://circ.ahajournals.org/content/136/1/6" target="_blank" >http://circ.ahajournals.org/content/136/1/6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026807" target="_blank" >10.1161/CIRCULATIONAHA.116.026807</a>

Result language

angličtina

Original language name

Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction

Original language description

BACKGROUND: Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Phenotyping patients into pathophysiologically homogeneous groups may enable better targeting of treatment. Obesity is common in HFpEF and has many cardiovascular effects, suggesting that it may be a viable candidate for phenotyping. We compared cardiovascular structure, function, and reserve capacity in subjects with obese HFpEF, those with nonobese HFpEF, and control subjects. METHODS: Subjects with obese HFpEF (body mass index &gt;= 35 kg/m(2); n=99), nonobese HFpEF (body mass index &lt; 30 kg/m(2); n=96), and nonobese control subjects free of HF (n=71) underwent detailed clinical assessment, echocardiography, and invasive hemodynamic exercise testing. CONCLUSIONS: Obesity-related HFpEF is a genuine form of cardiac failure and a clinically relevant phenotype that may require specific treatments.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Circulation

ISSN

0009-7322

e-ISSN

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Volume of the periodical

136

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

17

Pages from-to

6-19

UT code for WoS article

000404558500002

EID of the result in the Scopus database

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