Functional improvement after successful catheter ablation for long-standing persistent atrial fibrillation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00076205" target="_blank" >RIV/00023001:_____/17:00076205 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/17:00067917 RIV/00159816:_____/17:00067917

Result on the web

<a href="https://academic.oup.com/europace/article-abstract/19/11/1781/2952429" target="_blank" >https://academic.oup.com/europace/article-abstract/19/11/1781/2952429</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/europace/euw282" target="_blank" >10.1093/europace/euw282</a>

Result language

angličtina

Original language name

Functional improvement after successful catheter ablation for long-standing persistent atrial fibrillation

Original language description

Aims Identifying patients who benefit from restored sinus rhythm (SR) would optimize the selection of candidates for ablation of long-standing persistent atrial fibrillation (LSPAF). This prospective study sought to identify the hitherto unknown factors associated with global functional improvement after successful radiofrequency catheter ablation of LSPAF. Methods and results In 171 LSPAF patients (84% of the total consecutive 203 patients) who were examined in SR 12 months after ablation, the individual per cent change from baseline value in maximum oxygen consumption at exercise test (VO2 max), left ventricular ejection fraction (LVEF), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and five-dimensional descriptive system (EQ-5D) of quality-of-life questionnaire were classified in quartiles by 0 (worse) to 3 (best) grades. The individual grades were summed into a composite score (SCORE, 0... 12) reflecting global functional improvement. Significant improvement in VO2 max (3.4 +/- 4.7 mL/kg/min), LVEF (7.5 +/- 9.1%), NT-proBNP (-861 +/- 809 pg/mL), and EQ-5D (0.7 +/- 0.12) was observed (all P &lt; 0.0001). On multivariable analysis, younger age (P = 0.001), male gender (P = 0.02), timely post-ablation left atrial appendage (LAA) outflow (P = 0.005) with improvement in outflow velocity (P = 0.0002), and withdrawal of Class I/III antiarrhythmic drugs (P &lt; 0.05) were positively and independently correlated with the SCORE. Conclusions Younger male patients benefited most from catheter ablation of LSPAF. Delayed or non-improved LAA outflow and inability to discontinue Class I/III antiarrhythmic medication reduced the post-ablation functional improvement.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NR9143" target="_blank" >NR9143: Clinical benefit of right atrial lesions additional to the circumferential and linear lesions in the left atrium in ablative treatment of chronic atrial fibrillation - a prospective randomized study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Europace

ISSN

1099-5129

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1781-1789

UT code for WoS article

000414367100007

EID of the result in the Scopus database

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