The role of free radicals in autophagy regulation: Implications for ageing

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076568" target="_blank" >RIV/00023001:_____/18:00076568 - isvavai.cz</a>
Result on the web
<a href="https://www.hindawi.com/journals/omcl/2018/2450748/" target="_blank" >https://www.hindawi.com/journals/omcl/2018/2450748/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2018/2450748" target="_blank" >10.1155/2018/2450748</a>

Result language
angličtina
Original language name
The role of free radicals in autophagy regulation: Implications for ageing
Original language description
Reactive oxygen and nitrogen species (ROS and RNS, resp.) have been traditionally perceived solely as detrimental, leading to oxidative damage of biological macromolecules and organelles, cellular demise, and ageing. However, recent data suggest that ROS/RNS also plays an integral role in intracellular signalling and redox homeostasis (redoxtasis), which are necessary for the maintenance of cellular functions. There is a complex relationship between cellular ROS/RNS content and autophagy, which represents one of the major quality control systems in the cell. In this review, we focus on redox signalling and autophagy regulation with a special interest on ageing-associated changes. In the last section, we describe the role of autophagy and redox signalling in the context of Alzheimer's disease as an example of a prevalent age-related disorder.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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