Donor PNPLA3 rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076898" target="_blank" >RIV/00023001:_____/18:00076898 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1590865818301282?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1590865818301282?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dld.2017.12.030" target="_blank" >10.1016/j.dld.2017.12.030</a>
Alternative languages
Result language
angličtina
Original language name
Donor PNPLA3 rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study
Original language description
Background & aims: The rs738409 c.444C > G (p.I148M) polymorphism in PNPLA3 is a major factor predisposing to non-alcoholic fatty liver disease. The aim of the study was to clarify the impact of liver and extrahepatic expression of the PNPLA3 p.148M variant on liver graft steatosis after liver transplantation. Methods: Fat content was assessed in liver biopsies from 176 transplant recipients. During a period of 4 +/- 1 years after transplantation, 17 patients developed grade 3 steatosis, 14 patients grade 2 steatosis, 56 patients grade 1 steatosis, and 89 patients grade 0 steatosis. The influence of the recipient and donor rs738409 genotype and clinical and laboratory data on liver fat content were analyzed using ordinal logistic regression. Results: The PNPLA3 rs738409 CC/CG/GG genotype frequencies, respectively, were 0.494/0.449/0.057 in the graft donors and 0.545/0.330/0.125 in the graft recipients. In the multivariate analysis, the presence of the PNPLA3 c.444G allele in donor (OR 1.62; 95% CI 1.12-2.33), post-transplant BMI (OR 1.14; 95% CI 1.07-1.22), diabetes mellitus (OR 1.99; 95% CI 1.22-3.22), and serum triglycerides (OR 1.40; 95% CI 1.11-1.76) were independent risk factors for increased liver graft fat content. Conclusions: These data indicate that the liver expression of the PNPLA3 p.148M variant confers a genetic predisposition to liver graft steatosis along with nutritional status and diabetes.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30213 - Transplantation
Result continuities
Project
<a href="/en/project/NV15-26906A" target="_blank" >NV15-26906A: Genetic, transcriptomic and metabolic profiles of patients after liver transplantation with respect to the development of NAFLD/NASH.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Digestive and liver disease
ISSN
1590-8658
e-ISSN
—
Volume of the periodical
50
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
490-495
UT code for WoS article
000429911700011
EID of the result in the Scopus database
2-s2.0-85041009361