Can point shear wave elastography differentiate focal nodular hyperplasia from hepatocellular adenoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076942" target="_blank" >RIV/00023001:_____/18:00076942 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcu.22603" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcu.22603</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jcu.22603" target="_blank" >10.1002/jcu.22603</a>
Alternative languages
Result language
angličtina
Original language name
Can point shear wave elastography differentiate focal nodular hyperplasia from hepatocellular adenoma
Original language description
Purpose Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are liver tumors that require different management. We assessed the potential of point shear wave elastography (pSWE) to differentiate FNH from HCA and the interobserver and intraobserver reliability of pSWE in the examination of these lesions and of native liver tissue (NLT). Methods The study included 88 patients (65 FNH, 23 HCA). pSWE was performed by two experienced liver sonographers (observers 1 [O1] and 2 [O2]) and acquired within the lesion of interest and NLT. Group differences, optimal cutoff for characterization and interobserver reliability was assessed with Mann-Whitney-U, area under the ROC curce (AUROC) and intraclass correlation coefficient (ICC). Intraobserver reliability in NLT was assessed in 20 healthy subjects using ICC. Results Median stiffness was significantly higher in FNH than in HCA (7.01 kPa vs 4.98 kPa for O1 (P=0.017) and 7.68 kPa vs 6.00 kPa for O2 (P=0.031)). A cutoff point for differentiation between the two entities could not be determined with an AUROC of 0.67 (O1) and 0.69 (O2). Interobserver reliability was good for lesion- stiffness (ICC=0.86) and poor for NLT stiffness (ICC=0.09). In healthy subjects, intraobserver reliability for NLT-stiffness was poor for O1 (ICC=0.23) and moderate for O2 (ICC=0.62). Conclusion This study shows that pSWE cannot reliably differentiate FNH from HCA. Interobserver and intraobserver reliability for pSWE in NLT were insufficient. Interpretation of results gained with this method should be done with great caution.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of clinical ultrasound : JCU
ISSN
0091-2751
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
380-385
UT code for WoS article
000434419400002
EID of the result in the Scopus database
2-s2.0-85046689969&