Reply to Hernandez et al. - GWAS of acute renal graft rejection

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077068" target="_blank" >RIV/00023001:_____/18:00077068 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/ajt.14877" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1111/ajt.14877</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ajt.14877" target="_blank" >10.1111/ajt.14877</a>

Result language
angličtina
Original language name
Reply to Hernandez et al. - GWAS of acute renal graft rejection
Original language description
We were able to identify and validate the association of 2 genetic loci (CCDC67 and PTPRO) with biopsy-proven T cell–mediated rejection (TCMR). We concentrated our efforts on building a discovery cohort of cases with very low immunological risk. Kidney graft–rejecting cases were all European adults (>18 years of age), not or minimally sensitized, transplanted with a first kidney allograft under calcineurin inhibitors-based immunosuppressive regimen including induction. We ensured that phenotypes were correct and precise. Rejection was of TCMR type and histologically proven. We agree with Hernandez et al that the phenotypic heterogeneity they allowed in their study (cellular and humoral rejections were not distinguished, biopsy was not required, and combined ransplantations were accepted) may have diluted a true genetic association with TCMR in kidney recipients.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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