Steroid regulation: An overlooked aspect of tolerance and chronic rejection in kidney transplantation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077191" target="_blank" >RIV/00023001:_____/18:00077191 - isvavai.cz</a>
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0303720718300443?token=D1542D61A1DF4DD24754064318927E2E6319B36DCC625279BDD4AD216C237593CC86C6CB0778A3BF7E081AF26DE661E5" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0303720718300443?token=D1542D61A1DF4DD24754064318927E2E6319B36DCC625279BDD4AD216C237593CC86C6CB0778A3BF7E081AF26DE661E5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mce.2018.01.021" target="_blank" >10.1016/j.mce.2018.01.021</a>

Result language
angličtina
Original language name
Steroid regulation: An overlooked aspect of tolerance and chronic rejection in kidney transplantation
Original language description
Steroid conversion (HSD11B1, HSD11B2, H6PD) and receptor genes (NR3C1, NR3C2) were examined in kidney-transplant recipients with "operational tolerance" and chronic rejection (CR), independently and within the context of 88 tolerance-associated genes. Associations with cellular types were explored. Peripheral whole-blood gene-expression levels (RT-qPCR-based) and cell counts were adjusted for immunosuppressant drug intake. Tolerant (n = 17), stable (n = 190) and CR patients (n = 37) were compared. Healthy controls (n = 14) were used as reference. The anti-inflammatory glucocorticoid receptor (NR3C1) and the cortisol-activating HSD11B1 and H6PD genes were up-regulated in CR and were lowest in tolerant patients. The pro-inflammatory mineralocorticoid gene (NR3C2) was downregulated in stable and CR patients. NR3C1 was associated with neutrophils and NR3C2 with T-cells. Steroid conversion and receptor genes, alone, enabled classification of tolerant patients and were major contributors to gene-expression signatures of both, tolerance and CR, alongside known tolerance-associated genes, revealing a key role of steroid regulation and response in kidney transplantation.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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