Early isolated V-lesion may not truly represent rejection of the kidney allograft
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077408" target="_blank" >RIV/00023001:_____/18:00077408 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/18:00324438 RIV/00216208:11110/18:10382779 RIV/00023736:_____/18:00012443
Result on the web
<a href="http://www.clinsci.org/content/ppclinsci/132/20/2269.full.pdf" target="_blank" >http://www.clinsci.org/content/ppclinsci/132/20/2269.full.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1042/CS20180745" target="_blank" >10.1042/CS20180745</a>
Alternative languages
Result language
angličtina
Original language name
Early isolated V-lesion may not truly represent rejection of the kidney allograft
Original language description
Intimal arteritis is known to be a negative prognostic factor for kidney allograft survival. Isolated v-lesion (IV) is defined as intimal arteritis with minimal tubulointerstitial inflammation (TI). Although the Banff classification assesses IV as T cell-mediated rejection (TCMR), clinical, and prognostic significance of early IV (early IV, eIV) with negative C4d and donor-specific antibodies (DSA) remains unclear. To help resolve if such eIV truly represents acute rejection, a molecular study was performed. The transcriptome of eIV (n= 6), T cell-mediated vascular rejection with rich TI (T cell-mediated vascular rejection, TCMRV, n= 4) and non-rejection histologic findings (n= 8) was compared using microarrays. A total of 310 genes were identified to be deregulated in TCMRV compared with eIV. Gene enrichment analysis categorized deregulated genes to be associated primarily with T-cells associated biological processes involved in an innate and adaptive immune and inflammatory response. Comparison of deregulated gene lists between the study groups and controls showed only a 1.7% gene overlap. Unsupervised hierarchical cluster analysis revealed clear distinction of eIV from TCMRV and showed similarity with a control group. Up-regulation of immune response genes in TCMRV was validated using RT-qPCR in a different set of eIV (n= 12) and TCMRV (n= 8) samples. The transcriptome of early IV (< 1 month) with negative C4d and DSA is associated with a weak immune signature compared with TCMRV and shows similarity with normal findings. Such eIV may feature non-rejection origin and reflect an injury distinct from an alloimmune response. The present study supports use of molecular methods when interpreting kidney allograft biopsy findings.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical science
ISSN
0143-5221
e-ISSN
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Volume of the periodical
132
Issue of the periodical within the volume
20
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
2269-2284
UT code for WoS article
000449102900009
EID of the result in the Scopus database
2-s2.0-85055618177