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Skeletal muscle abnormalities and iron deficiency in chronic heart failure an exercise P-31 magnetic resonance spectroscopy study of calf muscle

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077443" target="_blank" >RIV/00023001:_____/18:00077443 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.ahajournals.org/doi/abs/10.1161/CIRCHEARTFAILURE.117.004800" target="_blank" >https://www.ahajournals.org/doi/abs/10.1161/CIRCHEARTFAILURE.117.004800</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004800" target="_blank" >10.1161/CIRCHEARTFAILURE.117.004800</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Skeletal muscle abnormalities and iron deficiency in chronic heart failure an exercise P-31 magnetic resonance spectroscopy study of calf muscle

  • Original language description

    BACKGROUND: Heart failure (HF) is often associated with iron deficiency (ID). Skeletal muscle abnormalities are common in HF, but the potential role of ID in this phenomenon is unclear. In addition to hemopoiesis, iron is essential for muscle bioenergetics. We examined whether energetic abnormalities in skeletal muscle in HF are affected by ID and if they are responsive to intravenous iron. METHODS AND RESULTS: Forty-four chronic HF subjects and 25 similar healthy volunteers underwent P-31 magnetic resonance spectroscopy of calf muscle at rest and during exercise (plantar flexions). Results were compared between HF subjects with or without ID. In 13 ID-HF subjects, examinations were repeated 1 month after intravenous ferric carboxymaltose administration (1000 mg). As compared with controls, HF subjects displayed lower resting high-energy phosphate content, lower exercise pH, and slower postexercise PCr recovery. Compared with non-ID HF, ID-HF subjects had lower muscle strength, larger PCr depletion, and more profound intracellular acidosis with exercise, consistent with an earlier metabolic shift to anaerobic glycolysis. The exercise-induced PCr drop strongly correlated with pH change in HF group (r=-0.71, P&lt;0.001) but not in controls (r=0.13, P=0.61, interaction: P&lt;0.0001). Short-term iron administration corrected the iron deficit but had no effect on muscle bioenergetics assessed 1 month later. CONCLUSIONS: HF patients display skeletal muscle myopathy that is more severe in those with iron deficiency. The presence of ID is associated with greater acidosis with exercise, which may explain early muscle fatigue. Further study is warranted to identify the strategy to restore iron content in skeletal muscle.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Circulation. Heart failure

  • ISSN

    1941-3289

  • e-ISSN

  • Volume of the periodical

    11

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    "art. no. e004800"

  • UT code for WoS article

    000453590600004

  • EID of the result in the Scopus database

    2-s2.0-85055606104