Skeletal muscle abnormalities and iron deficiency in chronic heart failure an exercise P-31 magnetic resonance spectroscopy study of calf muscle

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077443" target="_blank" >RIV/00023001:_____/18:00077443 - isvavai.cz</a>

Result on the web

<a href="https://www.ahajournals.org/doi/abs/10.1161/CIRCHEARTFAILURE.117.004800" target="_blank" >https://www.ahajournals.org/doi/abs/10.1161/CIRCHEARTFAILURE.117.004800</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004800" target="_blank" >10.1161/CIRCHEARTFAILURE.117.004800</a>

Result language

angličtina

Original language name

Skeletal muscle abnormalities and iron deficiency in chronic heart failure an exercise P-31 magnetic resonance spectroscopy study of calf muscle

Original language description

BACKGROUND: Heart failure (HF) is often associated with iron deficiency (ID). Skeletal muscle abnormalities are common in HF, but the potential role of ID in this phenomenon is unclear. In addition to hemopoiesis, iron is essential for muscle bioenergetics. We examined whether energetic abnormalities in skeletal muscle in HF are affected by ID and if they are responsive to intravenous iron. METHODS AND RESULTS: Forty-four chronic HF subjects and 25 similar healthy volunteers underwent P-31 magnetic resonance spectroscopy of calf muscle at rest and during exercise (plantar flexions). Results were compared between HF subjects with or without ID. In 13 ID-HF subjects, examinations were repeated 1 month after intravenous ferric carboxymaltose administration (1000 mg). As compared with controls, HF subjects displayed lower resting high-energy phosphate content, lower exercise pH, and slower postexercise PCr recovery. Compared with non-ID HF, ID-HF subjects had lower muscle strength, larger PCr depletion, and more profound intracellular acidosis with exercise, consistent with an earlier metabolic shift to anaerobic glycolysis. The exercise-induced PCr drop strongly correlated with pH change in HF group (r=-0.71, P&lt;0.001) but not in controls (r=0.13, P=0.61, interaction: P&lt;0.0001). Short-term iron administration corrected the iron deficit but had no effect on muscle bioenergetics assessed 1 month later. CONCLUSIONS: HF patients display skeletal muscle myopathy that is more severe in those with iron deficiency. The presence of ID is associated with greater acidosis with exercise, which may explain early muscle fatigue. Further study is warranted to identify the strategy to restore iron content in skeletal muscle.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Circulation. Heart failure

ISSN

1941-3289

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

"art. no. e004800"

UT code for WoS article

000453590600004

EID of the result in the Scopus database

2-s2.0-85055606104