Coronary artery disease is associated with an increased amount of T lymphocytes in human epicardial adipose tissue
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00077674" target="_blank" >RIV/00023001:_____/19:00077674 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10392504 RIV/00064165:_____/19:10392504
Result on the web
<a href="https://www.hindawi.com/journals/mi/2019/4075086/" target="_blank" >https://www.hindawi.com/journals/mi/2019/4075086/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2019/4075086" target="_blank" >10.1155/2019/4075086</a>
Alternative languages
Result language
angličtina
Original language name
Coronary artery disease is associated with an increased amount of T lymphocytes in human epicardial adipose tissue
Original language description
Immunocompetent cells including lymphocytes play a key role in the development of adipose tissue inflammation and obesity-related cardiovascular complications. The aim of the study was to explore the relationship between epicardial adipose tissue lymphocytes and coronary artery disease (CAD). To this end, we studied the content and phenotype of lymphocytes in peripheral blood, subcutaneous adipose tissue (SAT), and epicardial adipose tissue (EAT) in subjects with and without CAD undergoing elective cardiac surgery. Eleven subjects without CAD (non-CAD group) and 22 age-, BMI-, and HbA(1C)-matched individuals with CAD were included into the study. Blood, SAT, and EAT samples were obtained at the beginning of surgery. Lymphocyte populations were quantified as % of CD45+ cells using flow cytometry. Subjects with CAD had a higher total lymphocyte amount in EAT compared with SAT (32.24 +/- 7.45 vs. 11.22 +/- 1.34%, p=0.025) with a similar trend observed in non-CAD subjects (29.68 +/- 7.61 vs. 10.13 +/- 2.01%, p=0.067). T (CD3+) cells were increased (75.33 +/- 2.18 vs. 65.24 +/- 4.49%, p=0.032) and CD3- cells decreased (21.17 +/- 2.26 vs. 31.64 +/- 4.40%, p=0.028) in EAT of CAD relative to the non-CAD group. In both groups, EAT showed an elevated percentage of B cells (5.22 +/- 2.43 vs. 0.96 +/- 0.21%, p=0.039 for CAD and 12.49 +/- 5.83 vs. 1.16 +/- 0.19%, p=0.016 for non-CAD) and reduced natural killer (NK) cells (5.96 +/- 1.32 vs. 13.22 +/- 2.10%, p=0.012 for CAD and 5.32 +/- 1.97 vs. 13.81 +/- 2.72%, p=0.022 for non-CAD) relative to SAT. In conclusion, epicardial adipose tissue in subjects with CAD shows an increased amount of T lymphocytes relative to non-CAD individuals as well as a higher number of total and B lymphocytes and reduced NK cells as compared with corresponding SAT. These changes could contribute to the development of local inflammation and coronary atherosclerosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/NV15-26854A" target="_blank" >NV15-26854A: The role of epicardial adipose tissue in heart disease: novel mechanisms of action and its therapeutic modulation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mediators of inflammation [online]
ISSN
0962-9351
e-ISSN
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Volume of the periodical
2019
Issue of the periodical within the volume
February 2019
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
"art. no. 4075086"
UT code for WoS article
000459077000001
EID of the result in the Scopus database
2-s2.0-85063274859