Endothelial progenitor cells biology in diabetes mellitus and peripheral arterial disease and their therapeutic potential

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00077847" target="_blank" >RIV/00023001:_____/19:00077847 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/content/pdf/10.1007/s12015-018-9863-4.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s12015-018-9863-4.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12015-018-9863-4" target="_blank" >10.1007/s12015-018-9863-4</a>

Result language
angličtina
Original language name
Endothelial progenitor cells biology in diabetes mellitus and peripheral arterial disease and their therapeutic potential
Original language description
Endothelial progenitors are a population of cells with the inherent capacity to differentiate into mature endothelial cells and proangiogenic paracrine action. These characteristics have led to extensive studies being performed and tested in the treatment of tissue ischemia. The natural course of diabetes mellitus (DM) results in multiple areas of vascular damage. Thus endothelial progenitor cells(EPCs) beneficial potential is particularly desirable in diabetic patients. In this review, we summarize contemporary knowledge of EPC biology in DM. It has been shown that EPC functions are considerably impaired by DM. The presence of peripheral arterial disease (PAD) seems to further exacerbate the deficiencies of EPCs. However, studies examining EPC counts in PAD and DM observed disparate results, which can be due to a lack of consensus on precise EPC immunotype used in the different studies. Nevertheless, the results of EPC-based autologous cell therapy (ACT) are promising. In addition, EPCs have been shown to bean independent predictor of cardiovascular risk and diabetic foot ulcer healing.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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