Different acute effects of fructose and glucose administration on hepatic fat content
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078196" target="_blank" >RIV/00023001:_____/19:00078196 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/19:10409248
Result on the web
<a href="https://academic.oup.com/ajcn/article-abstract/109/6/1519/5480599?redirectedFrom=fulltext" target="_blank" >https://academic.oup.com/ajcn/article-abstract/109/6/1519/5480599?redirectedFrom=fulltext</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/ajcn/nqy386" target="_blank" >10.1093/ajcn/nqy386</a>
Alternative languages
Result language
angličtina
Original language name
Different acute effects of fructose and glucose administration on hepatic fat content
Original language description
Background: Diets rich in fat and added sugars (especially fructose) play an important role in the pathogenesis of nonalcoholic liver disease (NAFLD), but there is only limited information on the acute effects of these nutrients on hepatic fat content (HFC). Objectives: We therefore explored how the administration of high-fat load, glucose, fructose, and combinations thereof affects HFC measured in vivo using proton magnetic resonance spectroscopy (H-1-MRS) in healthy subjects. Methods: Ten healthy nonsteatotic male volunteers (age 38.5 +/- 9.6 y, body mass index [BMI, kg/m(2)] 26.9 +/- 2.7) underwent, in random order, 6 experiments, each lasting 8 h, that included: 1) fasting; 2) a high-fat load (150 g of fat [dairy cream] at time 0); 3) glucose (3 doses of 50 g at 0, 2, and 4 h); 4) a high-fat load with glucose; 5) fructose (3 doses of 50 g at 0, 2, and 4 h); and 6) a high-fat load with fructose. HFC was measured using 1H-MRS prior to test meal administration (before time 0) and at 3 and 6 h. Plasma concentrations of triglycerides, nonesterified fatty acids, glucose, and insulin were monitored throughout each experiment. Results: HFC increased to 119 +/- 19% (P < 0.05) and 117 +/- 17% (P < 0.01) of baseline when subjects consumed a high-fat load alone or a high-fat load with fructose, respectively, but was not affected when glucose was coadministered with a high-fat load. HFC was not affected when subjects had fasted or had consumed repeated doses of fructose. When subjects were administered 3 doses of glucose, HFC dropped to 85 +/- 13% (P < 0.05) of baseline. Conclusions: Our results demonstrate that fructose and glucose have a different immediate impact on HFC in humans in vivo.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/NV16-28427A" target="_blank" >NV16-28427A: Monitoring of hepatic fat metabolism using Magnetic Resonance methods</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American journal of clinical nutrition
ISSN
0002-9165
e-ISSN
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Volume of the periodical
109
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1519-1526
UT code for WoS article
000478066900005
EID of the result in the Scopus database
2-s2.0-85067278889