Abdominal aortic aneurysm as an IgG4-related disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078266" target="_blank" >RIV/00023001:_____/19:00078266 - isvavai.cz</a>
Alternative codes found
RIV/00023884:_____/19:00008167
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/cei.13307" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1111/cei.13307</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/cei.13307" target="_blank" >10.1111/cei.13307</a>

Result language
angličtina
Original language name
Abdominal aortic aneurysm as an IgG4-related disease
Original language description
The objectives of this study were to evaluate patients with aortic abdominal aneurysm (AAA) with regard to immunoglobulin (Ig)G4-related disease (IgG4-RD). IgG4-RD represents a recently defined condition comprised of a collection of disorders characterized by IgG4 hypergammaglobulinemia, the presence of IgG4-positive plasma cells in organs affected with fibrotic or sclerotizing changes and typical histopathological features. It was identified as a possible cause of vasculitis in large vessels. Studies have been published on a possible association between inflammatory aortic or cardiovascular disease and IgG4-RD. We examined 114 patients with AAA requiring surgery in order to identify findings which are characteristic of IgG4-RD. Aneurysm samples from seven patients showed histopathological features consistent with IgG4-RD and the presence of IgG4(+) plasma cells. Only two of these seven patients showed elevated IgG4 serum levels higher 1 center dot 35 g/l. In five of the patients, the concentration of serum IgG4 was lower than 1 center dot 20 g/l, with the number of IgG4(+) plasma cells being higher than 50/high-power field. These findings were consistent with AAA being a heterogeneous group of inflammatory diseases with different pathogenesis.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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