The relationship of mitochondrial dysfunction and the development of insulin resistance in Cushing's syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078342" target="_blank" >RIV/00023001:_____/19:00078342 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10403093 RIV/00023728:_____/19:N0000078 RIV/00064165:_____/19:10403093
Result on the web
<a href="https://www.dovepress.com/the-relationship-of-mitochondrial-dysfunction-and-the-development-of-i-peer-reviewed-fulltext-article-DMSO" target="_blank" >https://www.dovepress.com/the-relationship-of-mitochondrial-dysfunction-and-the-development-of-i-peer-reviewed-fulltext-article-DMSO</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2147/DMSO.S209095" target="_blank" >10.2147/DMSO.S209095</a>
Alternative languages
Result language
angličtina
Original language name
The relationship of mitochondrial dysfunction and the development of insulin resistance in Cushing's syndrome
Original language description
Purpose: Cushing's syndrome is characterized by metabolic disturbances including insulin resistance. Mitochondrial dysfunction is one pathogenic factor in the development of insulin resistance in patients with obesity. We explored whether mitochondrial dysfunction correlates with insulin resistance and other metabolic complications. Patients and methods: We investigated the changes of mRNA expression of genes encoding selected subunits of oxidative phosphorylation system (OXPHOS), pyruvate dehydrogenase (PDH) and citrate synthase (CS) in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM) and mitochondrial enzyme activity in platelets of 24 patients with active Cushing's syndrome and in 9 of them after successful treatment and 22 healthy control subjects. Results: Patients with active Cushing's syndrome had significantly increased body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and serum lipids relative to the control group. The expression of all investigated genes for selected mitochondrial proteins was decreased in SCAT in patients with active Cushing's syndrome and remained decreased after successful treatment. The expression of most tested genes in SCAT correlated inversely with BMI and HOMA-IR. The expression of genes encoding selected OXPHOS subunits and CS was increased in PM in patients with active Cushing's syndrome with a tendency to decrease toward normal levels after cure. Patients with active Cushing's syndrome showed increased enzyme activity of complex I (NQR) in platelets. Conclusion: Mitochondrial function in SCAT in patients with Cushing's syndrome is impaired and only slightly affected by its treatment which may reflect ongoing metabolic disturbances even after successful treatment of Cushing's syndrome.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetes, metabolic syndrome and obesity: Targets and therapy
ISSN
1178-7007
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
2019
Country of publishing house
NZ - NEW ZEALAND
Number of pages
13
Pages from-to
1459-1471
UT code for WoS article
000483444700001
EID of the result in the Scopus database
2-s2.0-85073344340