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The relationship of mitochondrial dysfunction and the development of insulin resistance in Cushing's syndrome

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078342" target="_blank" >RIV/00023001:_____/19:00078342 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/19:10403093 RIV/00023728:_____/19:N0000078 RIV/00064165:_____/19:10403093

  • Result on the web

    <a href="https://www.dovepress.com/the-relationship-of-mitochondrial-dysfunction-and-the-development-of-i-peer-reviewed-fulltext-article-DMSO" target="_blank" >https://www.dovepress.com/the-relationship-of-mitochondrial-dysfunction-and-the-development-of-i-peer-reviewed-fulltext-article-DMSO</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2147/DMSO.S209095" target="_blank" >10.2147/DMSO.S209095</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The relationship of mitochondrial dysfunction and the development of insulin resistance in Cushing's syndrome

  • Original language description

    Purpose: Cushing&apos;s syndrome is characterized by metabolic disturbances including insulin resistance. Mitochondrial dysfunction is one pathogenic factor in the development of insulin resistance in patients with obesity. We explored whether mitochondrial dysfunction correlates with insulin resistance and other metabolic complications. Patients and methods: We investigated the changes of mRNA expression of genes encoding selected subunits of oxidative phosphorylation system (OXPHOS), pyruvate dehydrogenase (PDH) and citrate synthase (CS) in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM) and mitochondrial enzyme activity in platelets of 24 patients with active Cushing&apos;s syndrome and in 9 of them after successful treatment and 22 healthy control subjects. Results: Patients with active Cushing&apos;s syndrome had significantly increased body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and serum lipids relative to the control group. The expression of all investigated genes for selected mitochondrial proteins was decreased in SCAT in patients with active Cushing&apos;s syndrome and remained decreased after successful treatment. The expression of most tested genes in SCAT correlated inversely with BMI and HOMA-IR. The expression of genes encoding selected OXPHOS subunits and CS was increased in PM in patients with active Cushing&apos;s syndrome with a tendency to decrease toward normal levels after cure. Patients with active Cushing&apos;s syndrome showed increased enzyme activity of complex I (NQR) in platelets. Conclusion: Mitochondrial function in SCAT in patients with Cushing&apos;s syndrome is impaired and only slightly affected by its treatment which may reflect ongoing metabolic disturbances even after successful treatment of Cushing&apos;s syndrome.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Diabetes, metabolic syndrome and obesity: Targets and therapy

  • ISSN

    1178-7007

  • e-ISSN

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    2019

  • Country of publishing house

    NZ - NEW ZEALAND

  • Number of pages

    13

  • Pages from-to

    1459-1471

  • UT code for WoS article

    000483444700001

  • EID of the result in the Scopus database

    2-s2.0-85073344340