IL28B rs12979860 T allele protects against CMV disease in liver transplant recipients in the post-prophylaxis and late period

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078388" target="_blank" >RIV/00023001:_____/19:00078388 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10400437

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/tid.13124" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1111/tid.13124</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/tid.13124" target="_blank" >10.1111/tid.13124</a>

Result language

angličtina

Original language name

IL28B rs12979860 T allele protects against CMV disease in liver transplant recipients in the post-prophylaxis and late period

Original language description

Background Cytomegalovirus (CMV) disease represents a serious complication in liver transplant (OLT) recipients. CMV prophylaxis reduces incidence of CMV disease in the early post-transplant period (on-prophylaxis disease, OPD) but may postpone its manifestation after the completion of prophylaxis. Post-prophylaxis disease (PPD) incidence after prophylaxis cessation may be modified by genetic factors. Methods We analyzed impact of IL28B rs1297986 variants on CMV disease incidence in 743 adult OLT recipients receiving universal prophylaxis. Results One hundred and forty-four (19.4%) patients had at least one CMV disease episode. One hundred and two of them (70.8%) had at least one OPD and 36 (25%) patients had PPD, six (4.2%) patients had both. The rate of IL28B T allele carriers was lower in PPD group (38.9%) in comparison with OPD group (66.7%, P = 0.005) and group without CMV disease (61.4%, P = 0.009). The impact of IL28B genotype on the risk of CMV OPD was significant neither in the allelic (TT + CT vs CC, P = 0.32) nor in the recessive model (TT vs CT + CC, P = 0.79). Contrarily, in the PPD group, T allele (TT + CT vs CC) had a protective effect, OR 0.4 (95% CI 0.2-0.8, P = 0.008). Further risk factors of PPD were age &lt;55 years and valganciclovir prophylaxis, whereas the risk factors of OPD were age &lt;55 years, cyclosporine A therapy and pre-transplant CMV serostatus (donor +/recipient -). Conclusions IL28B rs12979860 T allele carriers had a lower risk of CMV PPD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30213 - Transplantation

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transplant infectious disease

ISSN

1398-2273

e-ISSN

—

Volume of the periodical

21

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

"art. no. e13124"

UT code for WoS article

000481577000023

EID of the result in the Scopus database

2-s2.0-85067470820