Ganoderma Lucidum induces oxidative DNA damage and enhances the effect of 5-Fluorouracil in colorectal cancer in vitro and in vivo

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078460" target="_blank" >RIV/00023001:_____/19:00078460 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/19:00517497 RIV/68378041:_____/19:00517497 RIV/00216208:11140/19:10394482 RIV/00216208:11110/19:10394482 RIV/00216208:11120/19:43918356

Result on the web

<a href="https://reader.elsevier.com/reader/sd/pii/S1383571819300944?token=413953B527DD5225FA61C62E78A4956FCC480DAF936EC3FC13E739C52CF41F473B4BD30A8FCC1B81C45B4A8AE2DBF1FD" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1383571819300944?token=413953B527DD5225FA61C62E78A4956FCC480DAF936EC3FC13E739C52CF41F473B4BD30A8FCC1B81C45B4A8AE2DBF1FD</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mrgentox.2019.06.001" target="_blank" >10.1016/j.mrgentox.2019.06.001</a>

Result language

angličtina

Original language name

Ganoderma Lucidum induces oxidative DNA damage and enhances the effect of 5-Fluorouracil in colorectal cancer in vitro and in vivo

Original language description

The first-line chemotherapy of colorectal cancer (CRC), besides surgery, comprises administration of 5-Fluorouracil (5FU). Apart from cytotoxic effect on cancer cells, 5FU may also cause adverse side effects. Ganoderma Lucidum (GLC) is a mushroom used in Traditional Eastern Medicine. We propose that natural compounds, particularly GLC extracts, may sensitize cancer cells to conventional chemotherapeutics. This combination therapy could lead to more selective cancer cell death and may improve the response to the therapy and diminish the adverse effects of anticancer drugs. Here we demonstrate that GLC induced oxidative DNA damage selectively in colorectal cancer cell lines, whereas it protected non-malignant cells from the accumulation of reactive oxygen species. Accumulation of DNA damage caused sensitization of cancer cells to 5FU resulting in improved anticancer effect of 5FU. The results obtained in colorectal cell lines were confirmed in in vivo study: GLC co-treatment with 5FU increased the survival of treated mice and reduced the tumor volume in comparison with group treated with 5FU alone. Combination of conventional chemotherapeutics and natural compounds is a promising approach, which may reduce the effective curative dose of anticancer drugs, suppress their adverse effects and ultimately lead to better quality of life of CRC patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mutation Research. Genetic Toxicology and Environmental Mutagenesis

ISSN

1383-5718

e-ISSN

—

Volume of the periodical

845

Issue of the periodical within the volume

September

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

"art. no. 403065"

UT code for WoS article

000489193400017

EID of the result in the Scopus database

2-s2.0-85066812771