Clinical and Humoral Determinants of Congestion in Heart Failure: Potential Role of Adiponectin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078506" target="_blank" >RIV/00023001:_____/19:00078506 - isvavai.cz</a>

Result on the web

<a href="https://www.karger.com/Article/Pdf/502975" target="_blank" >https://www.karger.com/Article/Pdf/502975</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000502975" target="_blank" >10.1159/000502975</a>

Result language

angličtina

Original language name

Clinical and Humoral Determinants of Congestion in Heart Failure: Potential Role of Adiponectin

Original language description

Background: Some patients with heart failure (HF) are more prone to systemic congestion than others. The goal of this study was to identify clinical and humoral factors linked to congestion and its prognostic impact in HF patients. Methods: A total of 371 advanced HF patients underwent physical examination, echocardiography, right heart catheterization, blood samplings, and Minnesota Living with HF Questionnaire. Subjects were followed-up for adverse events (death, urgent transplantation, or assist device implantation without heart transplantation). Results: Thirty-one percent of patients were classified as prone to congestion. During a median follow-up of 1,093 days, 159 (43%) patients had an adverse event. In the Cox analysis, the congestion-prone (CP) status was associated with a 43% higher event risk. The CP status was strongly (p &lt; 0.001) associated with body weight loss, right ventricular dysfunction (RVD), dilated inferior vena cava (IVC), diuretics, and beta-blockers prescription and the majority of tested hormones in the univariate analysis. In the multivariate analysis, the only independent variables associated with the CP status were adiponectin, albumin, IVC diameter, and RVD. Adiponectin by itself was predictive of adverse events. In a multivariate model, CP status was no longer predictive of adverse events, in contrast to adiponectin. Conclusions: CP patients experienced more severe symptoms and had shorter survival. Potential role of adiponectin, a new independent predictor of CP status, should be further examined.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV17-28784A" target="_blank" >NV17-28784A: Mechanisms of right ventricular dysfunction in chronic heart failure</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Kidney and blood pressure research

ISSN

1420-4096

e-ISSN

—

Volume of the periodical

44

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

1271-1284

UT code for WoS article

000493120100035

EID of the result in the Scopus database

2-s2.0-85072805466