Clinical pregnancy after deceased donor uterus transplantation: Lessons learned and future perspectives

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078639" target="_blank" >RIV/00023001:_____/19:00078639 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/19:10400263 RIV/00216208:11140/19:10400263 RIV/00064203:_____/19:10400263

Result on the web

<a href="https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.13992" target="_blank" >https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.13992</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jog.13992" target="_blank" >10.1111/jog.13992</a>

Result language

angličtina

Original language name

Clinical pregnancy after deceased donor uterus transplantation: Lessons learned and future perspectives

Original language description

AIM: To describe our first clinical pregnancy following a uterus transplant from a brain-dead donor and to discuss current issues with deceased donor uterus transplantation as they relate to obstetrical success. METHODS: In August 2016, a 26-year-old woman with Mayer-Rokitansky-Küster-Hauser syndrome was the fourth person worldwide to receive a uterine transplant from a deceased donor and was the second in our trial. in vitro fertilization treatments using the long gonadotropin-releasing hormone agonist protocol preceded the transplantation procedure. Frozen embryo transfers were performed in months 12, 13, 16, 19 and 23 after transplant. RESULTS: Recovery of the uterus of a 24-year-old brain-dead nulliparous donor and the transplant procedure itself was uncomplicated. No abnormalities were revealed on Pap smears, which were performed every 6 months during the post-transplant period, and cervical biopsies showed no epithelial dysplasia. The fifth frozen embryo transfer resulted in a clinical pregnancy. Three weeks after embryo transfer, an intrauterine gestational sac containing an embryo with a heartbeat was detected. One week later, signs of a missed abortion were revealed by ultrasound. Two weeks later, spontaneous bleeding occurred, and an ultrasound examination performed a week later confirmed an empty uterine cavity. CONCLUSION: In light of present research, both deceased donor uterine procurement and transplantation surgeries are technically feasible; however, more experience is needed to determine the pregnancy success rate associated with this method. Thus, additional trials of deceased donor uterine transplantation should be performed in the future to continue research related to this promising concept for the treatment of absolute uterine factor infertility. © 2019 Japan Society of Obstetrics and Gynecology.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30213 - Transplantation

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of obstetrics and gynaecology research

ISSN

1341-8076

e-ISSN

—

Volume of the periodical

45

Issue of the periodical within the volume

8

Country of publishing house

JP - JAPAN

Number of pages

8

Pages from-to

1458-1465

UT code for WoS article

000478607700004

EID of the result in the Scopus database

2-s2.0-85065399886