New Imaging Markers of Clinical Outcome in Asymptomatic Patients with Severe Aortic Regurgitation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078654" target="_blank" >RIV/00023001:_____/19:00078654 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/19:10401247 RIV/00064173:_____/19:N0000063 RIV/00216208:11110/19:10401247 RIV/00064165:_____/19:10401247

Result on the web

<a href="https://www.mdpi.com/2077-0383/8/10/1654/htm" target="_blank" >https://www.mdpi.com/2077-0383/8/10/1654/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jcm8101654" target="_blank" >10.3390/jcm8101654</a>

Result language

angličtina

Original language name

New Imaging Markers of Clinical Outcome in Asymptomatic Patients with Severe Aortic Regurgitation

Original language description

Background: Determining the value of new imaging markers to predict aortic valve (AV) surgery in asymptomatic patients with severe aortic regurgitation (AR) in a prospective, observational, multicenter study. Methods: Consecutive patients with chronic severe AR were enrolled between 2015-2018. Baseline examination included echocardiography (ECHO) with 2- and 3-dimensional (2D and 3D) vena contracta area (VCA), and magnetic resonance imaging (MRI) with regurgitant volume (RV) and fraction (RF) analyzed in CoreLab. Results: The mean follow-up was 587 days (interquartile range (IQR) 296-901) in a total of 104 patients. Twenty patients underwent AV surgery. Baseline clinical and laboratory data did not differ between surgically and medically treated patients. Surgically treated patients had larger left ventricular (LV) dimension, end-diastolic volume (all p &lt; 0.05), and the LV ejection fraction was similar. The surgical group showed higher prevalence of severe AR (70% vs. 40%, p = 0.02). Out of all imaging markers 3D VCA, MRI-derived RV and RF were identified as the strongest independent predictors of AV surgery (all p &lt; 0.001). Conclusions: Parameters related to LV morphology and function showed moderate accuracy to identify patients in need of early AV surgery at the early stage of the disease. 3D ECHO-derived VCA and MRI-derived RV and RF showed high accuracy and excellent sensitivity to identify patients in need of early surgery.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV17-28265A" target="_blank" >NV17-28265A: Prognostic value of myocardial T1 mapping and global longitudinal speckle strain in patients with chronic aortic regurgitation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of clinical medicine

ISSN

2077-0383

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

10

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

"art. no. E1654"

UT code for WoS article

000498398500152

EID of the result in the Scopus database

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